Checkmate 227 plus#
The objective response rate was 45.3 percent in patients who received nivolumab plus ipilimumab, versus 26.9 percent in those who received PT-DC. “PFSat one year was nearly tripled, 43 percent versus13 percent, as was the duration of response at 1 year, 68 percent and 25 percent,” noted Hellmann. Of the 299 patients with high TMB, 139 received nivolumab plus ipilimumab and160 received chemotherapy.Īfter a minimum follow-up of 11.5 months, patients who received the immunotherapy combination were 42 percent less likely to have their disease progress compared with those who received PT-DC. “The first endpoint presented here examined PFS among patients with high TMB, which is an emerging biomarker that is independent of PD-L1 expression and characterises about 45 percent of patients with NSCLC,” Hellmann said.
Checkmate 227 trial#
This work also identifies TMB as an important and reliable biomarker that should be tested in patients with newly diagnosed NSCLC, he noted.ĬheckMate -227is a large, open-label, randomised phase III trial of nivolumab, nivolumab plus ipilimumab, or nivolumab plus platinum-doublet chemotherapy (PT-DC) versus PT-DC in patients with stage 4 or recurrent NSCLC who had not received prior treatment.ĭata from the comparison between the immunotherapy combination and PT-DC are being reported. “These practice-changing data establish the combination of nivolumab plus ipilimumab as a first-line treatment option for patients with high-TMB NSCLC,” Hellmann said. “The results show that in TMB-high NSCLC patients, nivolumab plus ipilimumab provides improved benefit compared to chemotherapy, increases benefit compared to anti-PD-1 monotherapy, yields durable responses, spares the use of chemotherapy in the first-line setting, and could preserve an effective option in the second line of therapy, if needed,” Hellmann added. “This context has yielded two critical opportunities for improvement: to develop effective combinations of therapy that can broaden the population of patients who respond to immunotherapy, and to identify effective biomarkers to predict response,” Hellmann explained. “While PD-1 immunotherapies have recently emerged as a critical new treatment option for this patient population, only a minority of all patients with NSCLC respond.” “Lung cancer is the greatest cause of cancer death worldwide and for most patients with newly diagnosed advanced NSCLC, chemotherapy has long been the standard,” said Matthew Hellmann, MD, assistant attending at Memorial Sloan Kettering Cancer Center. This study is also published in The New England Journal of Medicine.
![checkmate 227 checkmate 227](https://cdn.amebaowndme.com/madrid-prd/madrid-web/images/sites/424884/d2f1dfa1d4f1bf67a22f8f323dc7fbe0_532c80d987812ece5c1d1dee153d0e19.jpg)
![checkmate 227 checkmate 227](https://i.ytimg.com/vi/EQLriepvNjs/maxresdefault.jpg)
Among patients with newly diagnosed advanced non-small cell lung cancer (NSCLC) with high tumour mutational burden (TMB, >10 mutations/Mb), those who received nivolumab plus ipilimumab had significantly improved progression-free survival (PFS) compared with patients who received the standard-of-care chemotherapy, according to data from the phase III clinical trial CheckMate -227, presented at the AACR Annual Meeting 2018.